Inspired cell division is attributed to their free

Inspired by my father who is a professor in material sciences, I have always
been captivated by my surroundings and tried to understand them from different
aspects since young age. This spark of curiosity has guided me through my chase of
seeking answers for my questioning mind, and resulted in my strong passion
towards research. It is the main motivation behind my pursuit of graduate studies.
From second year of undergraduate study, I have dedicated myself to several
research projects, in domains of Mathematical Modeling, Super Resolution
Microscopy, DNA Biophysics, Microfluidics, and Fluid Dynamics. These valuable
experiences deepened my understanding of these cutting edge topics in science and
technology, and provided me chances to cultivate many experimental and analytical
skills. More importantly, I was inspired to decipher biological world with
interdisciplinary approach, which is well evidenced by the following research
experience of mine.
Professor Reyes-Lamothes has shown in his previous work that the even
distribution of bacterial high copy number plasmids at cell division is attributed to
their free diffusion, other than any molecular machinery that actively separates
them. Inspired by this result, I proposed a project aiming to uncover the
contribution of physics in this process in an in vitro model, which is based on
microfluidic platform. My knowledge in DNA polymer physics and microfluidic
system enabled me to design the experiments and complete the project almost
independently. My responsibilities included design and fabrication of the
microfluidic chips, surface characterization using SEM, DNA isolation, staining DNA
with intercalating fluorescent dyes, microscopy image acquisition, and data analysis
with a self-developed MATLAB algorithm. Throughout the project, I trained myself
toward an independent researcher who also functions equally well in a team
environment. Moreover, I demonstrated my ability to tackle obstacles and strong
perseverance. It was also a good opportunity for me to enrich my laboratory skills
and knowledge in both biophysics and molecular biology.
My hardworking has resulted in many awards, including Dean’s
multidisciplinary research list, Leonard Katz Science Undergraduate Research
Award and summer research fellowships, as well as being listed as second author in
an article that has been submitted for peer review recently. I was also selected to
present the above project at McGill Integrative Bioscience Student Society (MIBS)
research symposium.
In addition to my experience and skills in research, I have also prepared
myself for graduate study with a solid background in biology and mathematics. I
enrolled in courses, which would be of interest to me, challenge me, and aid me to
prepare for my future as a scientist regardless of how difficult they were, including
Bioinformatics, Biophysics, Imaging and Bio-instrumentation, Regression and
Analysis of Variance, Stochastic Processes, Molecular Biology, Nonlinear Dynamics
and a wide variety of courses in biology and quantitative subjects. Holding high  standards for myself and never settling for less, I always strive to grasp a deeper
understanding in each field than what is expected of me, even though my research
and courses covered a large range of topics. I welcome challenges with open arms
because they remind me that I could achieve anything once I put my mind to it. To
test my potentials, I enrolled in Putnam Mathematics Competition Seminar, where I
encountered numerous new ideas and techniques, and enhanced my logical and
critical thinking.
During my undergraduate study, I realized that my passion lies on
integrating engineering, mathematics, and physics to create and modify biological
component, such that it will meet people’s needs, and developing new techniques
that advances biological study. I believe that this kind of research is highly needed
and applicable to medical science, where the bridge between fundamental science
and clinical application should be urgently built. With these thoughts, I aim to
pursue my graduate study in Biomedical Engineering, particularly in the fields of
systems and synthetic biology, mechanobiology and biomaterials.
Studying under the supervision of the following professors would make my
graduate study both challenging and enjoyable since their work closely represents
my research interests: Professor Rong Fan who develops single cell analysis
techniques in order to debunk biological issues, such as cell signaling and
heterogeneity, and advance clinical monitoring and diagnosis; Professor Tarek
Fahmy who designs novel biomaterials that facilitate surgical therapy, drug delivery
and vaccine effectiveness; Professor Michael Murrell who probes the influence of
mechanical force on cell biology using various measurement techniques and
designing artificial cell models; Professor Mark Saltzman who develops biomaterials
that address medical issues, such as organ transplant, drug delivery, cancer
development and etc.
In addition to completing the Biomedical Engineering PhD program at Yale, I
also intend to further develop a specialty in quantitative biology in the Physical and
Engineering Biology (PEB) program. This unique opportunity will further broaden
my vision of science by enrolling in interdisciplinary courses, engaging in extensive
discussion on cutting edge research, and working with faculties and students with
various backgrounds.
Yale University is my dream school for graduate study. Learning and working
in the world-class academic environment of the Biomedical Engineering department
will definitely make me mature fast as a scientist in my field and accomplish great
achievements in the exciting research. The location of the university is another
attraction to me. Situated in the emerging center of biotechnology and medical care,
Yale certainly provides abundant opportunities and thriving environment for
collaboration and translational research.
I intend to pursue an academic career in Biomedical Engineering after
receiving my doctoral degree. As a researcher driven by curiosity, it is invigorating
for me to lead a life of discovery while contributing to the society. My ultimate goal
is to improve the quality of life. Working as a researcher in Biomedical Engineering
allows me to contribute at all level, from participating in fundamental research to
inventing solution of real-world problems. Last but not least, I enjoy teaching,
another important aspect of academic career, very much. My experience as teaching assistant and co-founding an education company during my gap year (since
September, 2017) can bear testimony to this fact.

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Hi!
I'm Shane!

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